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Target intelligence / Profile preview
Haemophilus influenzae type b Polysaccharide Capsule Conjugated to Tetanus Toxoid Protein Carrier (PRP-T)
- Target
- PRP-T
- Molecular classification
- Vaccine, Conjugate Vaccine, Polysaccharide-Protein Conjugate
01
Overview
The PRP-T vaccine is a conjugate vaccine designed to prevent invasive disease caused by Haemophilus influenzae type b (Hib). The vaccine consists of the capsular polysaccharide from Hib (PRP) covalently linked to tetanus toxoid protein carrier. This conjugation converts the immune response from T-cell independent to T-cell dependent, enhancing immunogenicity in infants and young children.
- Other names
- Hib conjugate vaccineActHIB®Hiberix®Polyribosyl-ribitol-phosphate tetanus toxoid conjugate vaccine
02
Mechanism of action
Stimulates a T-cell dependent immune response against Hib by conjugating the PRP antigen to tetanus toxoid, leading to production of anti-capsular antibodies that neutralize or opsonize Hib bacteria.
03
Biological functions
Induces humoral immune responseAntibody productionImmunological memory formationOpsonization of bacteria
04
Disease associations
Prevention of Haemophilus influenzae type b infectionsPrevention of meningitisPrevention of sepsis
05
Safety considerations
Local injection site reactions (pain, redness, swelling)FeverRarely, febrile seizures
06
Biomarkers
Anti-PRP antibody titers
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