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Target intelligence / Profile preview
Haemophilus influenzae type b Polysaccharide Conjugate Protein Carrier (Hib conjugate vaccine)
- Target
- Hib conjugate vaccine
- Molecular classification
- Polysaccharide, Protein, Conjugate Vaccine
01
Overview
The Haemophilus influenzae type b (Hib) polysaccharide conjugate protein carrier is a key component of Hib conjugate vaccines, which are designed to prevent invasive diseases caused by Haemophilus influenzae type b, such as meningitis, pneumonia, epiglottitis, and sepsis. The target molecule in these vaccines is the capsular polysaccharide of Hib—specifically polyribosyl-ribitol-phosphate (PRP)—which is covalently linked to a carrier protein to enhance immunogenicity.
- Other names
- PRP-TPRP-DHbOCPRP-OMPActHIB®Hiberix®PedvaxHIB®
02
Mechanism of action
Induces strong anti-PRP antibody response via T-cell dependent pathway
03
Biological functions
Immune responseAntibody productionVaccinationPrevention of infection
04
Disease associations
InfectionMeningitisPneumoniaEpiglottitisSepsis
05
Safety considerations
Local pain at injection siteLow-grade fever
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