Haemophilus influenzae type b polysaccharide conjugate protein carrier complex (Hib conjugate vaccine)

The Haemophilus influenzae type b (Hib) polysaccharide conjugate protein carrier complex is the active component in Hib vaccines. It consists of the PRP capsule of H. influenzae type b conjugated to a carrier protein (Tetanus toxoid, Diphtheria toxoid, CRM197, or Neisseria meningitidis OMP). Conjugation converts the T-cell independent PRP antigen into a T-cell dependent antigen, eliciting robust antibody production even in infants. Widespread use has dramatically reduced rates of severe Hib disease.

Other names

PRP-TPRP-DHbOCPRP-OMPHib vaccineHaemophilus influenzae type b vaccine

Converts T-independent B cell response to Hib polysaccharide into a T-dependent B cell response, resulting in enhanced antibody production, immunological memory, and protection against Haemophilus influenzae type b infections.