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Target intelligence / Profile preview
Haemophilus influenzae type b Polysaccharide Conjugated to Carrier Protein (Hib conjugate vaccine)
- Target
- Hib conjugate vaccine
- Molecular classification
- Vaccine, Conjugate Vaccine, Polysaccharide-protein conjugate
01
Overview
Haemophilus influenzae type b polysaccharide conjugated to a carrier protein is an engineered antigen designed for use in pediatric vaccination against invasive Hib infections. Its structure combines bacterial capsular sugar chains with an immunogenic foreign protein through chemical linkage—transforming a weakly immunogenic molecule into one capable of eliciting strong protective immunity across all age groups.
- Other names
- PRP-TTPRP-DPRP–CRM197PRP–OMPHib vaccine
02
Mechanism of action
Induces T-dependent immune response, leading to generation of high-affinity antibodies against Hib and immunologic memory formation.
03
Biological functions
Induction of humoral immunityAntibody productionImmunological memory formationPrevention of Haemophilus influenzae type b infection
04
Disease associations
Prevention of invasive Hib diseaseMeningitisEpiglottitisSepsis
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