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Haemophilus influenzae type b polysaccharide conjugated to tetanus protein (Hib-Tetanus Conjugate)

Target: Hib-Tetanus Conjugate
Molecular classification: Polysaccharide-protein conjugate, Vaccine antigen

Overview

Haemophilus influenzae type b (Hib) polysaccharide conjugated to tetanus protein is the active component in Hib conjugate vaccines. The antigen consists of purified capsular polysaccharide (PRP) from H. influenzae type b, covalently bound to inactivated tetanus toxoid. It induces a T-cell dependent immune response and strong antibody production against PRP, preventing invasive diseases caused by Haemophilus influenzae type b in young children.

Other names: Hib conjugate vaccineActHIBHiberixPedvaxHIBPolyribosylribitol phosphate conjugated to tetanus toxoidPRP-T

Mechanism of action

Induces a T-cell dependent immune response leading to the production of anti-PRP antibodies that provide protection against invasive Haemophilus influenzae type b disease.

Biological functions

Induction of humoral immunityAntibody productionPrevention of Haemophilus influenzae type b infection

Disease associations

InfectionMeningitisEpiglottitisPneumoniaSeptic arthritisPericarditis

Safety considerations

Mild pain at injection siteLow-grade feverRare severe adverse reactions

Interacting drugs

None (vaccine)

Biomarkers

Anti-PRP antibody concentration (protective level > 0.15 mcg/mL)

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