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Target intelligence / Profile preview
Haemophilus influenzae type b polysaccharide conjugated to tetanus toxoid (PRP-T)
- Target
- PRP-T
- Molecular classification
- Polysaccharide, Toxoid, Conjugate vaccine, Antigen
01
Overview
Haemophilus influenzae type b polysaccharide conjugated to tetanus toxoid is the active component in several Hib vaccines. It is designed for the prevention of invasive diseases caused by Haemophilus influenzae type b (Hib), a Gram-negative coccobacillus responsible for serious infections like sepsis and meningitis, especially in young children. The vaccine induces immunity by stimulating production of antibodies against the PRP capsule of Hib. Conjugation to tetanus toxoid enhances immunogenicity, particularly in infants who do not respond well to plain polysaccharides alone. Protective anti-PRP antibody levels correlate with protection against invasive disease.
- Other names
- Polyribosyl-ribitol-phosphate–Tetanus toxoidHaemophilus influenzae type B strain [1482/20,752] capsular polysaccharide-tetanus toxoid conjugate antigenHIBERIX® [Haemophilus b Conjugate Vaccine (Tetanus Toxoid Conjugate)]Hib-TT
02
Mechanism of action
Induces anti-Hib capsule antibodies via protein-conjugation-enhanced immune response
03
Biological functions
Immune responseAntigen presentationAntibody productionVaccination
04
Disease associations
InfectionHaemophilus influenzae type b infectionMeningitisSepsis
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