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Target intelligence / Profile preview
Haemophilus influenzae type b polysaccharide polyribosylribitol phosphate (PRP)
- Target
- PRP
- Molecular classification
- Polysaccharide, Capsular Polysaccharide, Antigen
01
Overview
Polyribosylribitol phosphate (PRP) is an essential capsular polysaccharide from Haemophilus influenzae type b. It forms linear chains with alternating ribose and ribitol-phosphate residues. As both a critical virulence factor enabling bacterial survival within hosts and an effective vaccine target when protein-conjugated, it has been central to preventing childhood invasive Hib disease worldwide through vaccination programs.
- Other names
- Hib polysaccharidePolyribosylribitol phosphatePRP capsule
02
Mechanism of action
Antibody-mediated complement activation and opsonization following vaccination
03
Biological functions
Immune evasionComplement inhibitionOpsonization resistanceVaccine antigen
04
Disease associations
InfectionMeningitisPneumoniaSepticemia
05
Safety considerations
Limited immunogenicity in infants without conjugationPotential for vaccine failure in immunocompromised individuals
06
Interacting drugs
Hib conjugate vaccines
07
Biomarkers
Anti-PRP antibody levels
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