Target intelligence / Profile preview

Haemophilus influenzae type b PRP capsule conjugated to tetanus protein carrier (PRP-T)

Target: PRP-T
Molecular classification: Polysaccharide, Conjugate vaccine, Toxoid

Overview

The Haemophilus influenzae type b (Hib) PRP capsule conjugated to tetanus protein carrier is a conjugate vaccine used to prevent invasive diseases caused by Hib. The PRP polysaccharide from the Hib capsule is covalently linked to tetanus toxoid, transforming it into a T-cell dependent antigen, which elicits a stronger and longer-lasting immune response, even in infants. This vaccine has dramatically reduced the incidence of Hib-related diseases, such as meningitis, in vaccinated populations.

Other names: Hib conjugate vaccinePRP-tetanus toxoid conjugate vaccine

Mechanism of action

The conjugate vaccine elicits a T-cell dependent immune response against the Hib capsular polysaccharide, leading to the production of anti-PRP antibodies that neutralize the bacteria.

Biological functions

Antigen presentationImmune response inductionAntibody production

Disease associations

Infection

Safety considerations

Local injection site reactionsFeverAllergic reactions

Interacting drugs

None

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