HAGLR opposite strand long non-coding RNA (HAGLROS)

HAGLR opposite strand long non-coding RNA (HAGLROS) is a cytoplasmic lncRNA transcript, approximately 699 nucleotides long, located on chromosome 2q31.1. It acts as a competing endogenous RNA (ceRNA), primarily by “sponging” microRNAs such as miR-100, miR-330-5p, miR-206, and miR-135b-3p, resulting in increased expression of their protein targets—including mTOR, SMARCA5, SPRR1B, NOTCH3, COL10A1, and ATG5. HAGLROS is frequently upregulated in several cancer types, where it promotes cell proliferation, migration, invasion, autophagy, and inhibits apoptosis. Its expression correlates with increased tumor grade, advanced clinical stage, metastasis, and poor patient prognosis. These findings make HAGLROS a promising molecular target and biomarker in oncology, although no approved drugs currently target it directly.

Other names

HAGLROSHOXD antisense growth-associated long-stranded noncoding RNA (antisense to HOXD, though the primary canonical name above is preferred)

Not directly applicable; mechanistic studies indicate its cancer-promoting effects are mediated by “sponging” microRNAs (such as miR-100, miR-330-5p, miR-206, miR-135b-3p) and influencing downstream oncogenic protein expression or mTORC1 signaling. In theory, antisense oligonucleotides or RNA interference-based therapies could downregulate HAGLROS, reversing its oncogenic effects