Haloacid dehalogenase-like hydrolase domain-containing protein 3 (HDHD3)

Haloacid dehalogenase-like hydrolase domain-containing protein 3 (HDHD3) is a protein-coding gene in Homo sapiens. It encodes a member of the HAD-like hydrolase superfamily, which is characterized by a "haloacid dehalogenase" (HAD) fold structure and the potential for hydrolase activity. The protein consists of 251 amino acids and has a molecular weight of roughly 28 kDa. Gene Ontology (GO) annotations suggest its role in general metabolic processes and hydrolase activity, but its precise physiological substrate and metabolic pathway context remain unclear. Subcellular localization data show that HDHD3 is predominantly found in the nucleolus and also in vesicles in human cells. HDHD3 has several predicted or observed protein-protein interactions, but its clinical, therapeutic, and pharmacological relevance are not well established. No known drugs target HDHD3, and it is not currently considered a classic therapeutic target such as a receptor, transporter, or central metabolic enzyme. There are no well-described biological markers, safety concerns, or drug mechanisms known for this protein. The only disease association documented is with Plasmodium ovale malaria, but causality or therapeutic relevance has not been established. HDHD3 is mainly of biochemical and molecular biology interest due to its hydrolase classification and nucleolar localization.

Other names

C9orf158MGC129042810435D12RikLOC682946haloacid dehalogenase-like hydrolase domain containing 3