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Hamstring muscle group

01

Overview

The hamstring muscle group comprises three skeletal muscles located in the posterior compartment of the thigh: the biceps femoris, semimembranosus, and semitendinosus. These muscles originate from the ischial tuberosity of the pelvis and insert on the tibia and fibula bones of the lower leg. The hamstrings are innervated by the sciatic nerve and function primarily to flex the knee and extend the hip, enabling fundamental human movements such as walking, running, and climbing. While not a pharmaceutical target, hamstring tendons are clinically significant in orthopedic medicine, as they can be harvested as autografts for knee ligament reconstruction surgery.

Other names
Posterior thigh muscleshamstrings
02

Biological functions

Knee flexionHip extensionStabilization of the knee and hip jointsExternal and internal rotation of the lower legEnergy storage and force generation during movement
03

Disease associations

Not applicable as a drug target. However, hamstring muscles are subject to strain injuries commonly seen in sports

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