Hantaan virus and Puumala virus envelope glycoproteins Gn and Gc (HTNV Gn-Gc and PUUV Gn-Gc)

The Hantaan virus (HTNV) and Puumala virus (PUUV) Gn and Gc glycoproteins are the essential surface proteins of these orthohantaviruses, which are the primary causative agents of hemorrhagic fever with renal syndrome (HFRS) in Eurasia (PMID: 30715428). These glycoproteins are encoded by the viral M genomic segment and are synthesized as a precursor polyprotein that is co-translationally cleaved into Gn and Gc subunits (UniProt: P08668, P23457). On the viral envelope, they assemble into spikes that mediate attachment to host cell receptors, such as beta-3 integrins, and facilitate membrane fusion following endocytosis (PMID: 24501065). As the primary targets for the host's neutralizing antibody response, these glycoproteins are the central components of vaccine candidates, including bivalent DNA vaccines like pHTN-M and pPUU-M, which have been evaluated in clinical trials (PMID: 24501065). Targeting both HTNV and PUUV glycoproteins is a strategic approach to provide broad-spectrum protection against various hantavirus strains that cause HFRS across different geographic regions.

Other names

Hantaan virus G1 and G2 proteinsPuumala virus G1 and G2 proteinsHantavirus M segment glycoproteinsHTNV Gn/GcPUUV Gn/GcOrthohantavirus envelope glycoproteins

Induction of neutralizing antibodies that bind to the Gn and Gc surface glycoproteins, preventing viral attachment to host cell receptors and inhibiting pH-dependent membrane fusion (PMID: 30715428).