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Target intelligence / Profile preview
Hantaan Virus Glycoprotein (HTNV Glycoprotein)
- Target
- HTNV Glycoprotein
- Molecular classification
- Viral Glycoprotein, Envelope Protein
01
Overview
The Hantaan virus glycoproteins, Gn and Gc, are essential envelope proteins that mediate host cell attachment, entry, and membrane fusion. They assemble into tetrameric spikes on the virion surface, forming a distinctive lattice. These glycoproteins are major targets for neutralizing antibodies and are critical for viral pathogenesis, including the modulation of autophagy. They represent prime targets for vaccine and therapeutic antibody development.
- Other names
- Hantaan Virus Gn/GcHTNV Gn/GcG1/G2 glycoprotein complexHFRS glycoproteinsHantaan virus envelope proteins
02
Mechanism of action
N/A
03
Biological functions
Host cell attachmentViral entryMembrane fusionImmune recognitionVirion assemblyAutophagy modulation
04
Disease associations
Hemorrhagic fever with renal syndrome (HFRS)Hantaan virus infection
05
Safety considerations
Potential for off-target effects with immunotherapiesRisk of antibody-dependent enhancement (ADE)Viral escape mutations
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