Hantaan virus glycoprotein Gn (HTNV Gn) (HTNV Gn)

Hantaan virus glycoprotein Gn is a major structural component of the Hantaan orthohantavirus, the prototype virus responsible for Hemorrhagic Fever with Renal Syndrome (HFRS) (UniProt: P08668). It is a type I transmembrane protein that, together with the Gc glycoprotein, forms the viral envelope spikes necessary for host cell attachment and entry (PubMed: 30842675). Gn specifically mediates the interaction with host cell receptors, such as beta-3 integrins and decay-accelerating factor (DAF), facilitating the internalization of the virus (PubMed: 11160711). As the primary target for neutralizing antibodies, Gn is a focal point for the development of therapeutic monoclonal antibodies and various vaccine platforms, including DNA and subunit vaccines (PubMed: 24501061). Targeting Gn aims to block the initial stages of the viral infection cycle, thereby preventing the systemic vascular leakage and renal failure characteristic of HFRS. Understanding the antigenic structure of Gn is crucial for overcoming challenges such as viral diversity and potential antibody-dependent enhancement (PubMed: 30842675).

Other names

Hantaan orthohantavirus Gn proteinHTNV G1Envelope glycoprotein GnHantaan virus G1 glycoprotein

Neutralizing antibodies bind to the Gn protein to block viral attachment to host cell receptors and prevent subsequent membrane fusion and entry.