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Target intelligence / Profile preview
Hantaan virus glycoprotein Gn-Gc (Gn-Gc)
- Target
- Gn-Gc
- Molecular classification
- Viral protein, Glycoprotein, Fusion protein
01
Overview
The Hantaan virus surface spike consists of tightly associated heterodimers formed by two envelope glycoproteins—Gn and Gc—which together orchestrate host cell recognition via receptor binding (primarily through β3 integrin family members among others), facilitate endocytosis-mediated uptake, then trigger pH-dependent membrane fusion via structural rearrangements primarily within the class II fusogen domain present in Gc. These processes make them critical determinants not only of infectivity but also prime targets for immune intervention strategies such as vaccines or therapeutic monoclonal antibodies due to their exposed location on virions’ surfaces.
- Other names
- Envelope Glycoprotein ComplexSurface Glycoprotein SpikeG1-G2Gn (G1)Gc (G2)
02
Mechanism of action
Viral entry inhibition (potential)
03
Biological functions
Viral entryHost cell attachmentMembrane fusion
04
Disease associations
Hemorrhagic fever with renal syndrome (HFRS)Infection
05
Safety considerations
Potential for off-target effects if targeting host proteinsEliciting broadly neutralizing antibodies is challenging
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