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Target intelligence / Profile preview
H-Ras protein (H-Ras)
- Target
- H-Ras
- Molecular classification
- Small GTPase, Oncoprotein
01
Overview
The H-Ras protein is a small GTPase encoded by the HRAS gene, acting as a molecular switch in signal transduction pathways. It plays a crucial role in regulating cell division, differentiation, and survival. Mutations in HRAS can lead to oncogenic signaling, contributing to cancer development. H-Ras is part of the Ras superfamily, which includes other oncogenes like KRAS and NRAS. It is involved in the MAPK/ERK pathway and interacts with various effectors to modulate cellular processes. Despite its importance in cancer, targeting H-Ras remains challenging due to its complex signaling mechanisms.
- Other names
- Harvey Rat sarcoma viral oncogene homologtransforming protein p21
02
Mechanism of action
Inhibition of GTP binding or enhancement of GTPase activity to prevent oncogenic signaling
03
Biological functions
Signal transductionCell proliferationCell differentiationApoptosis
04
Disease associations
CancerCostello syndrome
05
Safety considerations
Challenges in targeting Ras proteins due to their complex signaling networks and lack of effective inhibitors
06
Interacting drugs
Various small molecule inhibitors targeting Ras signaling pathways
07
Biomarkers
Mutations in the HRAS gene, especially in Costello syndrome
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