HAUS augmin-like complex subunit 3 (HAUS3)

HAUS augmin-like complex subunit 3 (HAUS3) is a structural protein encoded by the HAUS3 gene and is a key component of the augmin complex, a hetero-octameric assembly required for robust microtubule nucleation within the mitotic spindle during cell division[2][4]. HAUS3 forms a dimer with HAUS5, contributing to the architecture and stability of the TIII tetramer subunit of the augmin complex[3][1][7]. The augmin complex, including HAUS3, is responsible for recruiting γ-tubulin to spindle microtubules, which is crucial for their organization, chromosome segregation, and integrity of centrosomes[2][4][1]. Loss or dysfunction of HAUS3 causes mitotic defects such as spindle disorder and fragmentation of centrosomes, which can contribute to carcinogenesis and other proliferative disorders[2][4]. HAUS3 is not classified as a receptor, enzyme, ion channel, or transporter, but rather as a structural element of a multi-protein complex critical for cell division. No direct therapeutic drugs or biomarkers are associated with HAUS3 to date[2][4].

Other names

IT1DGT3C4orf15MGC4701

Not applicable. No drugs are known to directly target HAUS3. Mechanistic modulation would involve disruption of spindle assembly, but this is not clinically pursued.