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HAUS augmin-like complex subunit 5 (HAUS5)
- Target
- HAUS5
- Molecular classification
- Other (component of the augmin complex; not classified as a receptor, enzyme, ion channel, or transporter)
01
Overview
HAUS augmin-like complex subunit 5 (HAUS5) is a core component of the augmin (HAUS) complex, an eight-subunit protein assembly that binds to and nucleates microtubules, facilitating robust mitotic spindle assembly and maintaining centrosome integrity during mitosis. HAUS5 plays a vital role in cell division by enabling microtubule formation along the mitotic spindle, ensuring proper chromosome segregation and cytokinesis. Loss or depletion of HAUS5 results in severe mitotic defects, such as centrosome fragmentation and mitotic arrest, compromising cell viability. HAUS5 is expressed at variable levels across tissues but is frequently upregulated in many cancers, correlating with tumor progression and poor prognosis. While it is a potential prognostic biomarker and emerging therapeutic target in oncology, there are currently no established drugs selectively targeting HAUS5.
- Other names
- KIAA0841DGT5dgt5
02
Mechanism of action
No drugs are established as directly targeting HAUS5; mechanisms would theoretically involve inhibition of microtubule assembly or mitotic spindle formation, similar to tubulin-binding agents
03
Biological functions
Microtubule nucleationMitotic spindle assemblyChromosome segregationMaintenance of centrosome integrityCytokinesisCell cycle regulation
04
Disease associations
Cancer (notably glioblastoma, breast cancer, hepatocellular carcinoma, and multiple other tumor types)Potential oncology biomarker
05
Safety considerations
Targeting HAUS5 is likely to cause major mitotic defects, leading to impaired cell division in both normal and cancer cells, raising significant toxicity and safety concerns such as cytopenias and off-tumor effects
06
Interacting drugs
None currently established; no known drugs directly target HAUS5. Microtubule-targeting agents (e.g., taxanes, vinca alkaloids) act on the spindle/microtubule apparatus but not specifically on HAUS5
07
Biomarkers
High HAUS5 mRNA/protein expression is a candidate biomarker for prognosis in certain cancers, including hepatocellular carcinoma and breast cancer
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