HAUS complex subunit 3–DNA polymerase nu readthrough protein (null)

This protein is the product of translational readthrough, where the ribosome bypasses a canonical stop codon to continue translating across adjacent open R\nreading frames of HAUS3 and POLN. Readthrough proteins can occur infrequently due to regulatory or sequence elements in mRNA[2][3][6]. Such fusion products may retain partial functions of their parental proteins—HAUS3 (a component involved in microtubule organization) and POLN (a specialized DNA polymerase involved in DNA repair)—but the specific structure, function, and physiological relevance of the HAUS3-POLN readthrough protein have not been established in the literature. There is no evidence for its therapeutic relevance or implications in human disease; its existence is annotated through bioinformatic prediction and ribosome profiling, not biochemical validation[2][6].

Other names

HAUS3-POLN readthrough proteinENSG00000290263HAUS Augmin-like complex subunit 3–DNA polymerase nu readthrough

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