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Target intelligence / Profile preview
Hazel Pollen Allergen
- Molecular classification
- Protein Allergen, Pathogenesis-related protein (PR-10), Isoflavone reductase homolog, Luminal binding protein
01
Overview
Hazel pollen allergen refers to proteins in the pollen of hazel trees (*Corylus* species) that trigger allergic reactions in sensitized individuals. The major allergens include Cor a 1 (homologous to Bet v 1), Cor a 6, and Cor a 10. Exposure leads to allergic rhinitis, conjunctivitis, asthma, and dermatitis. Diagnosis involves specific IgE testing. Management includes avoidance, pharmacotherapy, and allergen immunotherapy.
- Other names
- Cor a 1Cor a 6Cor a 10Corylus spp. pollenHazel tree pollen
02
Mechanism of action
Antihistamines: Block histamine receptors. Nasal corticosteroids: Reduce inflammation in nasal passages. Allergen immunotherapy: Induces tolerance to the allergen.
03
Biological functions
AllergenElicits IgE-mediated immune response
04
Disease associations
Allergic rhinitisConjunctivitisAsthmaAtopic dermatitis
05
Safety considerations
Anaphylaxis (rare, with allergen immunotherapy)Side effects of antihistamines (drowsiness, dry mouth)Side effects of nasal corticosteroids (nasal irritation, nosebleeds)
06
Interacting drugs
Antihistamines
2 more in the full profile.
07
Biomarkers
Specific IgE levels against hazel pollen allergens (Cor a 1, Cor a 6, Cor a 10)
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