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Target intelligence / Profile preview
HD domain-containing protein 2 (HDDC2)
- Target
- HDDC2
- Molecular classification
- Enzyme
01
Overview
HD domain-containing protein 2 (HDDC2) is an enzyme of the HD hydrolase superfamily that catalyzes the dephosphorylation of nucleoside 5'-monophosphates (especially dAMP, dCMP, dGMP, dTMP), facilitating nucleotide metabolism. The protein has been referenced as transactivated by hepatitis C virus NS5A in the literature, although its physiological and pathological roles beyond basic nucleotide catabolism remain largely understudied. There is currently no evidence for direct clinical targeting, biomarker use, or pharmacological intervention involving HDDC2[2][6][3][5].
- Other names
- 5'-deoxynucleotidase HDDC2C6orf74NS5ATP2CGI-130dJ167O5.2Hepatitis C virus NS5A-transactivated protein 2testicular tissue protein Li 83HD domain-containing protein 2
02
Biological functions
Dephosphorylation of nucleoside 5'-monophosphatesDeoxyribonucleoside monophosphate catabolic process
03
Disease associations
Infection
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