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Heat-labile enterotoxin B subunit (LTB)

Target: LTB
Molecular classification: Bacterial Toxin Subunit, AB5 toxin family

Overview

The heat-labile enterotoxin B subunit (LTB) is a component of the heat-labile enterotoxin (LT) produced by Escherichia coli (ETEC). LTB is a pentamer that binds to GM1 gangliosides on host cell membranes, facilitating the entry of the toxic LT-A subunit into cells. While non-toxic on its own, LTB plays a crucial role in the pathogenesis of ETEC-related diarrheal disease. It also exhibits immunomodulatory properties.

Other names: EtxBLT-BHeat-labile enterotoxin B chain

Mechanism of action

Facilitates the entry of the Heat-labile enterotoxin A subunit into host cells by binding to GM1 gangliosides.

Biological functions

Receptor bindingCellular entry facilitationImmunomodulation

Disease associations

InfectionDiarrheal disease (ETEC infection)

Safety considerations

While LTB itself is non-toxic, its role in delivering the toxic LT-A subunit poses a therapeutic challenge.Immunomodulatory properties could have unintended consequences.

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