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Target intelligence / Profile preview
Heat-labile enterotoxin subunit B (LT-B)
- Target
- LT-B
- Molecular classification
- Toxin subunit, Bacterial virulence factor
01
Overview
Heat-labile enterotoxin subunit B (LT-B) is a non-toxic component of the heat-labile enterotoxin (LT) produced by enterotoxigenic Escherichia coli (ETEC). It is responsible for binding to ganglioside GM1 receptors on host cell membranes, facilitating entry of the toxic A subunit into target cells. LT-B is highly immunogenic and used in vaccine development as an antigen and mucosal adjuvant.
02
Mechanism of action
Binds to ganglioside GM1 receptors on intestinal epithelial cells, facilitating entry of the heat-labile enterotoxin A subunit.
03
Biological functions
Host cell bindingReceptor-mediated endocytosis facilitationImmune stimulationAdjuvant activity
04
Disease associations
InfectionDiarrheal disease
05
Safety considerations
Potential for immune response if not properly isolated from the A subunit.
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