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HEAT repeat-containing protein 6 (HEATR6)
- Target
- HEATR6
- Molecular classification
- Protein containing HEAT-repeat motifs (HEAT repeat-containing protein), Other (does not fall into receptor, enzyme, transporter, ion channel, or transcription factor families)
01
Overview
HEAT repeat-containing protein 6 is a human protein encoded by the HEATR6 gene, located on chromosome 17. It contains HEAT (Huntingtin, Elongation factor 3, protein phosphatase 2A, and TOR1) repeat motifs, which typically enable protein-protein interactions and may participate in the assembly of multiprotein complexes. The protein is predicted to enable RNA binding and is amplified in various cancers, notably breast cancer, supporting a role as an amplification-dependent oncogene. Despite these associations, its precise molecular, cellular, and pathophysiological functions remain incompletely characterized, and no drugs are known to specifically target HEATR6 at this time.
- Other names
- ABC1amplified in breast cancer 1FLJ22087HEAT repeat-containing protein 6HEATR6amplified in breast cancer protein 1
02
Mechanism of action
None currently established; no known drug mechanism of action targeting this molecule
03
Biological functions
RNA bindingProtein-protein interactions (presumed based on HEAT repeats)Amplification-dependent oncogene activity
04
Disease associations
Cancer (association with breast cancer and polycystic kidney disease)
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