Heat shock 70 kDa protein 12A (HSPA12A)

Heat shock 70 kDa protein 12A (HSPA12A) is a member of the HSP70 family of molecular chaperones, sharing conserved domain architecture but possessing a divergent ATP-binding domain. HSPA12A acts as an adapter protein for SORL1 (SorLA), delaying SORL1 internalization and affecting its subcellular localization[1][3][6]. HSPA12A expression is upregulated during adipocyte differentiation and in obesity, where it regulates adipogenesis chiefly by maintaining PPARγ expression[2]. It is also implicated in hepatocellular carcinoma by binding PCNA, regulating PCNA trimerization and thereby influencing cell proliferation[4]. Cerebral expression of HSPA12A is high, with potential involvement in neurodegeneration and psychiatric disorders. Although not currently a direct drug target, its roles in protein folding, cell differentiation, membrane trafficking, and disease pathogenesis highlight its potential clinical relevance as a biomarker or therapeutic candidate in metabolic, neurodegenerative, and oncologic contexts[2][3][4][6].

Other names

HSPA12AKIAA0417FLJ13874Heat shock protein family A member 12Aheat shock 70kDa protein 12Aheat shock protein 70kDa 12A