Heat shock factor-binding protein 1-like protein 1 (HSBP1L1)

Heat shock factor-binding protein 1-like protein 1 (HSBP1L1) is a small, protein-coding gene product in humans, sharing homology with heat shock factor-binding protein 1 (HSBP1)[2][3][9]. HSBP1L1 is predicted to be a transcriptional corepressor and is involved in cellular heat acclimation processes[2]. Its structure and sequence suggest it is composed primarily of a coiled-coil oligomerization domain, and it is present in the cytosol and nucleus[2][3]. HSBP1L1 is an important paralog of HSBP1, which is a known negative regulator of the heat shock transcription factor HSF1, but there is limited functional information about the specific biological or pathological roles for HSBP1L1 in humans[2][3]. There are no known drugs targeting HSBP1L1, nor is it an established biomarker or therapeutic target. Its associations with disease are limited to rare conditions in genetic data, with no established mechanism or therapeutic application. Note: Most functional and disease information available for HSBP1L1 is predicted or indirect, often inferred from its relationship to HSBP1. Direct evidence for specific molecular functions or disease mechanisms is lacking[2][3].

Other names

FLJ10967MGC189743heat shock factor binding protein 1 like 1HSBP1L1