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Target intelligence / Profile preview
Heat Shock Protein 20 (Hsp20)
- Target
- Hsp20
- Molecular classification
- Heat shock protein, Molecular chaperone
01
Overview
Heat shock protein 20 (Hsp20) is a member of the heat shock protein family, acting as an ATP-independent molecular chaperone. It prevents irreversible aggregation of denatured proteins during cellular stress and plays key roles in proteostasis. In cardiac tissue, it protects against apoptosis, remodeling, and ischemia/reperfusion injury and modulates cardiac contractility. Its expression is induced by heat shock factors during cellular stress. Hsp20 is being explored as a potential therapeutic target for heart disease.
- Other names
- Small heat shock proteinsHSP
02
Mechanism of action
ATP-independent molecular chaperone; prevents irreversible aggregation of denatured proteins
03
Biological functions
Protein foldingChaperone activityProteostasisRegulation of cardiac contractilityApoptosis regulationInhibition of platelet aggregationGlucose transport regulationCytoskeletal dynamics
04
Disease associations
Cardiovascular diseasesNeurodegenerative diseaseCancerInflammation-related disordersImpaired glucose metabolism
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