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Target intelligence / Profile preview
Heat Shock Protein 27 (HSP27)
- Target
- HSP27
- Molecular classification
- Small heat shock protein (sHsp), Molecular chaperone
01
Overview
Heat shock protein 27 (HSP27) is a molecular chaperone belonging to the small heat shock protein family. It plays crucial roles in protein folding, antioxidant defense, and apoptosis inhibition. HSP27's expression is upregulated by various cellular stresses, and it is implicated in multiple diseases, including cancer, neurodegenerative disorders, cardiovascular diseases, and renal fibrosis. It is being explored as a therapeutic target, particularly in cancer, despite challenges in developing effective inhibitors.
- Other names
- Hsp27Heat shock protein beta-1HSPB1HspB1
02
Mechanism of action
Inhibition of HSP27 aims to disrupt its anti-apoptotic and pro-tumorigenic functions, often through interference with its oligomerization or phosphorylation.
03
Biological functions
Chaperone activityAntioxidant defenseAnti-apoptosisCytoskeletal remodelingSignal transduction
04
Disease associations
CancerNeurodegenerative diseaseCardiovascular diseaseRenal injury/fibrosisIschemia-reperfusion injury
05
Safety considerations
Lack of ATP-binding site makes it difficult to target with conventional chaperone inhibitorsDual protective and counter-protective roles depending on the context
06
Biomarkers
Diagnostic biomarker for cancerPrognostic biomarker for cancerDiagnostic biomarker for cardiovascular disordersPrognostic biomarker for cardiovascular disorders
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