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Heat Shock Protein 72 (Hsp72)

Target: Hsp72
Molecular classification: Heat Shock Protein 70 family, Molecular chaperone

Overview

Heat shock protein 72 (Hsp72) is a highly inducible member of the HSP70 family, playing a crucial role in cellular protection against stress. It functions as a molecular chaperone, facilitating proper protein folding, preventing aggregation, and assisting in the degradation of misfolded proteins. Hsp72 expression is upregulated by various stressors and is implicated in several diseases, making it a potential therapeutic target.

Other names: Heat shock 70 kDa protein 1HSPA1A

Mechanism of action

Modulation of protein folding and aggregation, influencing cell survival pathways.

Biological functions

Protein foldingProtein refoldingPrevention of protein aggregationAssisting in degradation/stabilization of misfolded proteinsDNA repairCytoskeletal maintenanceApoptosis suppression

Disease associations

Cancer progression/resistanceNeurodegenerative diseasesCell senescence/agingInflammatory diseases (e.g., type II diabetes, rheumatoid arthritis)Fibrosis (e.g., Crohn’s disease)

Safety considerations

Modulating Hsp72 expression could have broad effects on cellular proteostasis, requiring careful consideration of potential off-target effects.Inhibition of Hsp72 might impair cellular stress response and increase vulnerability to damage.

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