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Target intelligence / Profile preview
Heat Shock Protein 90 (Yeast Homolog HSP82) (HSP90/HSP82)
- Target
- HSP90/HSP82
- Molecular classification
- Molecular chaperone, Heat Shock Protein
01
Overview
Heat shock protein 90 (Hsp90) is a highly conserved and essential molecular chaperone found in all eukaryotes, including yeast. In *Saccharomyces cerevisiae* (baker’s yeast), the primary stress-inducible isoform is known as Hsp82. This protein plays a critical role in maintaining cellular proteostasis by assisting the folding, stabilization, and activation of a wide range of client proteins, many of which are involved in signal transduction pathways and cellular stress responses.
- Other names
- Hsp82Hsc82
02
Mechanism of action
Inhibition of chaperone activity, destabilization of client proteins
03
Biological functions
Protein foldingProtein stabilizationProtein activationSignal transductionStress responseRegulation of telomere maintenance
04
Disease associations
CancerNeurodegenerative diseaseOther
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