Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Heat Shock Protein 90 Alpha (HSP90α)
- Target
- HSP90α
- Molecular classification
- Molecular chaperone, Heat shock protein
01
Overview
Heat shock protein 90 alpha (HSP90α) is a highly conserved, stress-inducible molecular chaperone that plays a central role in maintaining protein homeostasis, especially under conditions of proteotoxic stress. It supports cell survival by regulating key processes such as cell cycle control, hormone signaling pathways, apoptosis regulation, DNA repair, and signal transduction cascades. HSP90α stabilizes many oncogenic proteins and is overexpressed in various cancers, supporting tumor growth and progression. It is a therapeutic target for cancer, with inhibitors and antibodies being developed to disrupt its function.
- Other names
- HSP90AA1Hsp90Heat shock 90 kDa protein 1, alpha
02
Mechanism of action
Inhibition of ATP binding to HSP90, disruption of HSP90 chaperone function, inhibition of client protein stabilization
03
Biological functions
Protein foldingProtein stabilizationSignal transductionCell cycle controlApoptosis regulationDNA repairImmune modulationProtein homeostasis
04
Disease associations
CancerNeurodegenerative disease (potential)Other
05
Safety considerations
Toxicity from inhibiting essential intracellular functions when using non-selective inhibitorsPotential for off-target effectsDevelopment of resistance
06
Interacting drugs
N-terminal ATP competitive inhibitors
3 more in the full profile.
07
Biomarkers
Cancer severity/progressioneHsp90α levels (extracellular)
Beyond the preview
Go deeper on Heat Shock Protein 90 Alpha (HSP90α).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Heat Shock Protein 90 Alpha (HSP90α).