Heat shock protein 90kDa alpha (cytosolic), class A member 6, pseudogene (HSP90AA6P)

HSP90AA6P is a human pseudogene that shares homology with the active heat shock protein 90kDa alpha (Hsp90α), a stress-inducible molecular chaperone involved in protein folding, stabilization, and degradation. Unlike its ancestral gene (HSP90AA1), HSP90AA6P does not encode a functional chaperone protein and thus does not participate directly in cellular stress response or protein homeostasis. Pseudogenes may have a coding-independent role at the RNA level, such as acting as a microRNA decoy, thereby modulating the expression of the parental gene and potentially influencing disease processes indirectly[6]. However, there is no experimental or clinical evidence indicating therapeutic target status, drug interaction, or established disease relevance for HSP90AA6P itself.

Other names

HSP90Afheat shock protein 90Afheat shock protein 90kDa alpha (cytosolic), class A member 1 pseudogeneheat shock protein 90kDa alpha (cytosolic), class A member 6, pseudogeneheat shock protein 90kDa alpha family class A member 6, pseudogene[2]

None for HSP90AA6P (noncoding pseudogene). For parental HSP90AA1 protein: inhibition of ATPase activity disrupts chaperone function, leading to cell death in tumor cells[3].