Heat shock protein beta-1 messenger RNA (HSPB1 mRNA) (HSPB1 mRNA)

Heat shock protein beta-1 (HSPB1) mRNA is the messenger RNA transcript that encodes Heat Shock Protein 27 (HSP27), a small heat shock protein and molecular chaperone [UniProt: P04792]. HSP27 is involved in protein folding, stabilization of the cytoskeleton, and the inhibition of apoptosis by binding to pro-apoptotic factors such as cytochrome c and DAXX [PubMed: 15034578]. In various malignancies, including prostate, bladder, and lung cancers, HSPB1 mRNA is frequently overexpressed, which promotes tumor cell survival and confers resistance to chemotherapy and radiation [PubMed: 24501014]. Therapeutic targeting of this mRNA is achieved using antisense oligonucleotides (ASOs), such as Apatorsen (OGX-427), which bind to the transcript and induce its degradation through RNase H-mediated cleavage [ClinicalTrials.gov: NCT01120470]. This reduction in HSP27 protein levels sensitizes cancer cells to standard treatments and inhibits tumor progression. Additionally, mutations in the HSPB1 gene are associated with neurodegenerative disorders like Charcot-Marie-Tooth disease, highlighting its critical role in cellular homeostasis [NCBI Gene ID: 3315].

Other names

HSP27 mRNAHeat shock 27kDa protein 1 mRNASRP27 mRNAHSPB1 transcript

Antisense oligonucleotide-mediated mRNA degradation via RNase H recruitment, resulting in the downregulation of Heat Shock Protein 27 (HSP27) protein expression [PubMed: 24501014].