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Target intelligence / Profile preview
Heat shock protein 70 kDa 1A (HSPA1A)
- Target
- HSPA1A
- Molecular classification
- Molecular chaperone, Heat shock protein
01
Overview
Heat shock protein 70 kDa 1A (Hsp72/HSPA1A) is an essential cytosolic chaperone that safeguards cells from proteotoxic stress through its roles in folding/refolding polypeptides and targeting damaged proteins for degradation. Its dysregulation contributes to diverse human diseases including cancer and neurodegeneration; it also serves potential biomarker functions due to its inducible expression profile under pathological conditions.
- Other names
- Hsp72Heat shock 70 kDa protein 1HSP70-1Heat shock protein family A member 1A
02
Mechanism of action
Not applicable, HSPA1A is a target
03
Biological functions
Protein folding/refoldingSubcellular transportFormation/dissociation of multi-protein complexesProteostasis maintenanceDNA repairApoptosis regulationCell growth/differentiation
04
Disease associations
CancerNeurodegenerative disordersDiabetes mellitus type IIRheumatoid arthritisCell senescence/aging-related pathologies
05
Biomarkers
Elevated circulating levels may serve as biomarkers for certain cancers such as breast carcinoma progression
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