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Target intelligence / Profile preview
Heat shock protein family A member 5 (HSPA5)
- Target
- HSPA5
- Molecular classification
- Heat shock protein, Molecular chaperone
01
Overview
HSPA5, also known as BiP or GRP78, is an endoplasmic reticulum (ER) resident chaperone protein belonging to the HSP70 family. It plays a crucial role in protein folding, quality control, and regulating the unfolded protein response (UPR). HSPA5 is essential for maintaining cellular homeostasis and is implicated in various diseases, including infections and cancer, making it a therapeutic target.
- Other names
- BiPGRP78Glucose-Regulated Protein, 78kDaEndoplasmic Reticulum Chaperone BiPHeat Shock 70kDa Protein 5Immunoglobulin Heavy Chain-Binding Protein
02
Mechanism of action
Modulation of HSPA5 activity to restore cellular homeostasis and enhance sensitivity to therapy.
03
Biological functions
Protein foldingQuality control of protein foldingUnfolded protein response (UPR) regulationER protein transportStress response
04
Disease associations
MucormycosisJapanese EncephalitisCoronavirus diseases/COVID-19Chemoresistant cancers
05
Safety considerations
Potential for off-target effects due to broad chaperone function.Modulation of UPR can have complex and context-dependent effects.
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