Heat shock protein family B member 1 pseudogene 1 (HSPB1P1)

Heat shock protein family B member 1 pseudogene 1 (HSPB1P1) is a non-protein-coding pseudogene, derived from the parental HSPB1 gene, which encodes heat shock protein beta-1. While HSPB1P1 does not produce a functional protein, it is abnormally expressed across multiple human cancers. Elevated HSPB1P1 RNA levels are correlated with cancer progression and poor prognosis, particularly in hepatocellular carcinoma. Functional studies indicate that HSPB1P1 may regulate gene expression by acting as a ceRNA, modulating pathways such as EZH2 signaling in cancer. It is not a traditional therapeutic target but may serve as a prognostic biomarker and a candidate for future RNA-based therapies.

Other names

heat shock protein beta-1 pseudogene 1HSPB1 pseudogene 1Pseudogene HSPB1P1

As a pseudogene, HSPB1P1 may act as a regulatory RNA affecting expression of other genes (such as EZH2 in hepatocellular carcinoma) through ceRNA mechanisms.