Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Heat shock protein family B member 9 (HSPB9)
- Target
- HSPB9
- Molecular classification
- Small heat shock protein, Chaperone protein, Alpha-crystallin domain-containing protein
01
Overview
Heat shock protein family B member 9 (HSPB9) is a member of the small heat shock protein (sHSP/HSP20) family[4][1]. It is characterized by a conserved alpha-crystallin domain, essential for its ATP-independent chaperone activity, preventing protein aggregation and maintaining proteostasis during cellular stress[3][1][4]. HSPB9 is predominantly expressed in the testis and is considered a cancer/testis antigen (CT51), signifying occasional expression in certain cancers and utility in cancer immunology studies[2][6]. Unlike some other HSPBs, HSPB9's expression and function remain less characterized, with limited evidence linking it to major human diseases or therapeutic applications[5].
- Other names
- Heat shock protein beta-9HspB9CT51Cancer/testis antigen 51Heat shock protein, alpha-crystallin-related, B9Small heat shock protein B9
02
Biological functions
Protein folding/chaperone activityCytoprotection in response to cellular stressPrevention of protein aggregationMaintenance of cytoskeletal integrityPotential anti-apoptotic activity
03
Disease associations
Cancer (as a cancer/testis antigen, occasionally detected in cancer)Cataract (association through paralogs, not directly by HSPB9)Motor neuron disease (by gene association; not strong evidence for HSPB9 directly)Other (testis-specific antigens)
Beyond the preview
Go deeper on Heat shock protein family B member 9 (HSPB9).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Heat shock protein family B member 9 (HSPB9).