Heat shock protein family D member 1 (HSPD1)

Heat shock protein family D member 1 (HSPD1, commonly called HSP60) is a mitochondrial chaperonin that plays an essential role in protein folding, refolding misfolded proteins, and preventing protein aggregation. HSPD1 is critical for maintaining proper mitochondrial function and contributes to cell survival during physiological and environmental stress. In cancer, HSPD1 is often upregulated, promoting tumor cell survival, proliferation, metastasis (by repressing E-cadherin and enhancing migration/invasion), and angiogenesis. Extracellular HSPD1 has immune-modulating activities within the tumor microenvironment. Pathogenic mutations in the HSPD1 gene are associated with neurodegenerative diseases and may contribute to cardiovascular and inflammatory disorders due to disrupted protein homeostasis

Other names

HSP60Chaperonin 60mitochondrial 60 kDa heat shock proteinCpn60HSPD1_HUMAN

Inhibition of protein-folding activity (disruption of chaperonin function)\nInduction of apoptosis in cancer cells through mitochondrial dysfunction\nModulation of tumor microenvironment and immune response