Heat shock protein family E member 1 pseudogene 23 (HSPE1P23)

HSPE1P23 is a processed pseudogene in the human genome labeled as **heat shock protein family E (Hsp10) member 1 pseudogene 23**. It is homologous to the functional heat shock protein family E member 1 (HSPE1, also known as Hsp10), which is a mitochondrial chaperonin involved in protein folding during stress. However, as a pseudogene, HSPE1P23 contains disrupting mutations or lacks regulatory elements, and thus does not produce a functional protein product[1][4][6]. Processed pseudogenes like HSPE1P23 are generated by reverse transcription of mRNA and reintegration into the genome, typically lacking introns and often containing frame disruptions that prevent functional protein production[4]. Recent research on pseudogenes in general highlights their potential regulatory roles at the RNA level, including acting as decoys for miRNAs or producing regulatory small RNAs, but no such regulatory function has been specifically described for HSPE1P23[2][6]. There is no evidence that HSPE1P23 is a therapeutic target, biomarker, or is associated with drug interactions, nor does it have direct disease or safety concerns attributed to it[1][4][6].