Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Heat shock protein HSP 90-beta (Hsp90β)
- Target
- Hsp90β
- Molecular classification
- Molecular chaperone, Heat Shock Protein
01
Overview
Heat shock protein HSP 90-beta (Hsp90β) is a constitutively expressed molecular chaperone found in the cytoplasm of eukaryotic cells. It is one of two major cytoplasmic isoforms of HSP90 in vertebrates. Hsp90β assists folding, stabilization, activation, and assembly/disassembly of many client proteins and maintains cellular homeostasis by preventing aggregation/misfolding. Dysregulation or overexpression is implicated in various diseases, particularly cancer, where it supports the stability and functionality of mutated oncoproteins. Inhibitors targeting its ATPase activity are being developed as potential therapeutics.
02
Mechanism of action
Inhibition of ATPase activity leading to destabilization of client oncoproteins.
03
Biological functions
Protein foldingProtein stabilizationProtein assembly/disassemblyCell cycle controlSignal transductionApoptosis regulationProtein quality controlMaintaining cellular homeostasis
04
Disease associations
CancerNeurodegenerative diseaseCataractsInfectious diseases
05
Safety considerations
Potential for broad effects due to interaction with numerous client proteins.Development of resistance to inhibitors.
06
Interacting drugs
Hsp90 inhibitors (targeting ATPase activity)
1 more in the full profile.
Beyond the preview
Go deeper on Heat shock protein HSP 90-beta (Hsp90β).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Heat shock protein HSP 90-beta (Hsp90β).