Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Heat shock protein HSP90-alpha (HSP90AA1)
- Target
- HSP90AA1
- Molecular classification
- Molecular chaperone, Enzyme
01
Overview
Heat shock protein HSP90-alpha (HSP90AA1) is a highly conserved and essential molecular chaperone involved in the folding, stabilization, and regulation of a wide array of client proteins, many of which are critical for cell signaling, growth, and survival. It functions as an ATP-dependent chaperone, assisting in protein folding, refolding, and stabilization. HSP90-alpha plays a central role in cancer due to its stabilization of multiple oncogenic signaling molecules, making it a therapeutic target for anti-cancer agents.
- Other names
- HSPCAHSPC1HSP90AHSP86 ProteinHeat shock 86 kDa protein alpha (cytosolic), member A1Renal carcinoma antigen NY-REN-38Lipopolysaccharide-associated protein 2 (LAP-2)LPS-associated protein 2
02
Mechanism of action
Inhibition of ATPase activity, leading to destabilization and degradation of client proteins.
03
Biological functions
Protein foldingProtein stabilizationRegulation of client proteinsSignal transductionCell growthCell survival
04
Disease associations
CancerAcute upper respiratory infectionAsthma
05
Safety considerations
Potential for off-target effects due to the broad range of client proteins.Development of resistance.
06
Interacting drugs
Geldanamycin derivatives (e.g., BIIB021)
Beyond the preview
Go deeper on Heat shock protein HSP90-alpha (HSP90AA1).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Heat shock protein HSP90-alpha (HSP90AA1).