Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Heat shock protein HSP90-beta (HSP90β)
- Target
- HSP90β
- Molecular classification
- Heat shock protein 90 family, Molecular chaperone
01
Overview
Heat shock protein HSP90-beta (HSP90β) is a molecular chaperone encoded by the *HSP90AB1* gene. It assists in protein folding, refolding, and stabilization, and targets damaged proteins for degradation. It's essential for cellular proteostasis and is upregulated under stress. HSP90β supports multiple disease-relevant pathways, particularly in cancer, making it a target for drug development. However, clinical translation faces challenges due to toxicity and compensatory mechanisms.
- Other names
- HSP90BHSP90AB1
02
Mechanism of action
Inhibition of ATP binding, leading to destabilization of client proteins and their subsequent degradation
03
Biological functions
Protein foldingProtein stabilizationProtein degradationStress responseIntracellular transportRegulation of apoptosis
04
Disease associations
CancerNeurodegenerative diseaseCardiovascular diseaseInfection
05
Safety considerations
ToxicityCompensatory mechanisms
06
Interacting drugs
HSP90 inhibitors
Beyond the preview
Go deeper on Heat shock protein HSP90-beta (HSP90β).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Heat shock protein HSP90-beta (HSP90β).