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Target intelligence / Profile preview
Heat Shock Transcription Factor 2 Binding Protein (HSF2BP)
- Target
- HSF2BP
- Molecular classification
- Transcription factor-associated protein, Protein binding factor
01
Overview
HSF2BP is a protein that binds to Heat Shock Transcription Factor 2 (HSF2). It plays roles in meiotic recombination and repair, and has been implicated in protecting against liver injury by regulating the heat shock response pathway, specifically through the HSF2BP/HSP70/MAPK axis[1][2]. It is also associated with premature ovarian failure and male fertility[2][5].
- Other names
- MEILB2POF19
02
Mechanism of action
Inhibition of MAPK pathway activation (JNK1/2 and P38 MAPK), upregulation of HSP70 and HSF2 expression, and binding to HSF2 to modulate transcription of heat shock proteins.
03
Biological functions
Signal transductionCell death regulation (anti-apoptosis role)Meiotic recombination and repairModulation of heat shock response
04
Disease associations
Liver injuryPremature ovarian failure (POI)Primary ovarian insufficiency
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