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Target intelligence / Profile preview
Heat shock transcription factor Y-linked 1 (HSFY1)
- Target
- HSFY1
- Molecular classification
- Transcription factor
01
Overview
Heat shock transcription factor Y-linked 1 (HSFY1) is a member of the heat shock factor (HSF) family of transcriptional activators with a specific role in regulating the transcription of heat shock proteins in response to cellular stress. HSFY1 is located on the Y chromosome, with two identical copies present. It is specifically expressed in the testis and has been implicated as a potential genetic factor in male infertility, particularly azoospermia, due to its localization in regions frequently deleted in infertile males. HSFY1 encodes protein isoforms through alternative splicing, but currently, there are no known drug interactions or roles in other major diseases outside reproduction[2][3][4][7].
- Other names
- Heat shock transcription factor, Y-linkedHSFYHSF2LHeat shock transcription factor 2-like protein
02
Biological functions
DNA-binding transcription factor activitysequence-specific DNA bindingregulation of heat shock protein expression
03
Disease associations
AzoospermiaSpermatogenic failure
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