HECT and RLD domain containing E3 ubiquitin protein ligase 2 pseudogene 5 (HERC2P5)

HERC2 pseudogene 5 (HERC2P5) is a non-coding RNA pseudogene derived from the parental HERC2 gene, which encodes a large HECT-type E3 ubiquitin ligase involved in diverse processes such as DNA repair, cell cycle regulation, pigmentation, and tumor suppression. As a pseudogene, HERC2P5 itself does not code for a functional protein and is not considered a therapeutic target, receptor, enzyme, or transporter. Its primary biological role remains undefined, though pseudogenes in the HERC2 family may play a role in regulation of gene expression or act as long non-coding RNAs potentially involved in cancer-associated pathways, as seen in related pseudogenes like HERC2P2. There is no evidence that HERC2P5 affects disease risk, serves as a drug target, or has known biomarker or safety implications[3][4]. Key clarification: - HERC2P5 is a pseudogene—it does not produce a protein or serve as a receptor or druggable target, and is therefore not considered a therapeutic target. - Information on related pseudogenes (e.g., HERC2P2) suggests possible involvement in cancer biology at the RNA level, but HERC2P5 itself lacks specific published functional or pathological roles[3][4]. - Most biological roles, drug interactions, and functional mechanisms discussed for HERC2 apply only to the protein-coding parental gene (HERC2), not to HERC2P5[1][2][3][4][5]. - This entry may be incorrect or unsuitable for a drug/target database focused on functional proteins. Summary: HERC2P5 (D16F37S6) is a non-coding pseudogene related to the HERC2 gene; it is not a protein-coding gene, therapeutic target, or receptor, and its precise biological significance is currently unknown, though analogous pseudogenes may have regulatory non-coding RNA functions in certain diseases[3][4].

Other names

D16F37S6hect domain and RLD 2 pseudogene 5HERC2P5