HECT domain E3 ubiquitin protein ligase 3 (HECTD3)

HECT domain E3 ubiquitin protein ligase 3 (HECTD3) is an enzyme in the HECT family of E3 ubiquitin ligases, characterized by possession of a C-terminal HECT domain that forms a thioester intermediate with ubiquitin to catalyze its transfer from an E2 conjugating enzyme to substrate proteins[4]. This activity controls protein fate—often marking proteins for degradation by the proteasome, but also modulating signaling, cell-cycle processes, and protein activity or localization[7][8]. The HECT ligase family plays pivotal roles in cellular homeostasis and pathophysiology, with individual members implicated in cancer and other diseases[1][3][8]. HECTD3 belongs to the “other” subfamily of the HECT E3 ligases, distinguished from the NEDD4 and HERC subfamilies by its unique N-terminal architecture[1][2][3]. While the full scope of HECTD3-specific biologic and clinical roles is still being investigated, dysregulation of HECT E3 ligases broadly is linked to oncogenesis, neurodegenerative disease, and other pathogenic processes[1][8].

Other names

HECT domain-containing protein 3HECT-type E3 ubiquitin transferase HECTD3FLJ21156

Catalyzes transfer of ubiquitin from an E2 conjugating enzyme to substrate proteins via a catalytic cysteine, forming a thioester intermediate. Targets substrate proteins for ubiquitin-mediated degradation or functional modification[7][8]