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Target intelligence / Profile preview
Helicase for meiosis 1 (HFM1)
- Target
- HFM1
- Molecular classification
- Enzyme, Helicase, ZMM group member
01
Overview
HFM1 is an ATP-dependent DNA helicase that plays a critical role in homologous recombination during meiosis I, particularly facilitating crossover formation, synapsis, and proper spindle assembly/division in germ cells. It is highly expressed in oocytes and spermatocytes, and its activity ensures genome stability and efficient chromosome segregation in gametogenesis. Knockout or genetic mutation of HFM1 leads to misaligned chromosomes, spindle formation defects, loss of ovarian reserve, and infertility. Mutations in HFM1 are associated with primary ovarian insufficiency in women and idiopathic oligo/azoospermia in men; hence, HFM1 is regarded as a significant biomarker and genetic target in reproductive medicine.
- Other names
- MER3POF9SEC63D1Si-11Si-11-6
02
Mechanism of action
Not applicable for drugs, as there are currently no known specific inhibitors or activators.
03
Biological functions
Homologous recombination in meiosisDNA repairOocyte maturationSpindle assembly and division during meiosisGenome stability
04
Disease associations
Primary ovarian insufficiency/premature ovarian failure (POI/POF)Infertility (female and male)Idiopathic oligo/azoospermia (male infertility)Potentially other chromosomal segregation disorders; not well-characterized outside reproductive context.
05
Safety considerations
Loss-of-function mutations cause germ cell depletion, subfertility, and meiotic defectsTherapeutic targeting could risk gametogenesis, chromosomal segregation, and reproductive competence.
06
Biomarkers
HFM1 mutationsGenetic screening for HFM1 variants is proposed for reproductive disorders.
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