Helicase-like transcription factor (HLTF)

Helicase-like transcription factor (HLTF) is a multifunctional enzyme and chromatin remodeler belonging to the SWI/SNF family, with roles in DNA repair, transcription regulation, and protein remodeling at stalled replication forks. HLTF contains a HIRAN DNA-binding domain, a SWI/SNF-like helicase domain, and a RING finger domain conferring E3 ubiquitin ligase activity. Through its dsDNA translocase activity, HLTF orchestrates fork remodeling and regression to facilitate template-switching-based, error-free DNA damage bypass. HLTF is considered a tumor suppressor, frequently inactivated via promoter methylation or sporadic alternative splicing in colorectal and gastric cancers. Loss of HLTF function compromises cellular resistance to DNA damage and is associated with increased sensitivity to UV and genotoxic agents[1][2][3][4].

Other names

HIP116ARNF80SMARCA3SNF2L3ZBU1HLTF1HIP116RING finger protein 80RING-type E3 ubiquitin transferase HLTFSWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 3Sucrose nonfermenting protein 2-like 3DNA-binding protein/plasminogen activator inhibitor 1 regulator