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Target intelligence / Profile preview
Helicobacter pylori (H. pylori)
- Target
- H. pylori
- Molecular classification
- Bacterium, Gram-negative bacteria, Microaerophilic bacteria
01
Overview
Helicobacter pylori (H. pylori) is a gram-negative, microaerophilic bacterium that colonizes the human stomach. Its unique adaptations allow it to survive in the acidic environment, making it a significant pathogen. It is associated with gastritis, peptic ulcers, and gastric cancer. Treatment typically involves antibiotics and proton pump inhibitors. Eradication is becoming more difficult with increasing antibiotic resistance.
02
Mechanism of action
Antibiotics target bacterial cell wall synthesis, protein synthesis, or DNA replication. PPIs reduce stomach acid production. Bismuth subsalicylate has antimicrobial and anti-inflammatory effects.
03
Biological functions
Colonization of the stomachUrease productionAdhesion to gastric epitheliumBiofilm formationHydrogen utilization
04
Disease associations
GastritisPeptic ulcerGastric cancerNutrient malabsorption
05
Safety considerations
Antibiotic resistanceTreatment failure due to biofilm formationSide effects of antibiotics (e.g., nausea, diarrhea)PPI-related risks (e.g., increased risk of Clostridium difficile infection, bone fractures)
06
Interacting drugs
Amoxicillin
5 more in the full profile.
07
Biomarkers
Urease breath testStool antigen testSerum antibodies
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