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Target intelligence / Profile preview
Helicobacter pylori Adhesion to Gastric Epithelial Cells (H. pylori Adhesion)
- Target
- H. pylori Adhesion
- Molecular classification
- Adhesin-Receptor Interaction, Outer Membrane Protein Interaction, Glycan Binding
01
Overview
Helicobacter pylori adhesion to gastric epithelial cells is a critical early step in the pathogenesis of H. pylori infection, enabling the bacterium to colonize the human stomach and resist clearance. This process is mediated by specific interactions between bacterial adhesins (e.g., BabA, SabA) and host cell receptors (e.g., Lewis antigens, CEACAMs) on the gastric epithelium, facilitating colonization, virulence factor delivery, and induction of chronic inflammation, which can lead to gastritis, ulcers, or gastric cancer.
- Other names
- H. pylori adherenceHelicobacter pylori colonizationH. pylori attachment
02
Mechanism of action
Interference with adhesin-receptor binding; disruption of bacterial cell wall integrity; inhibition of bacterial growth.
03
Biological functions
ColonizationAdherencePersistenceVirulenceImmune evasion
04
Disease associations
GastritisPeptic Ulcer DiseaseGastric CancerHelicobacter pylori infection
05
Safety considerations
Antibiotic resistanceDevelopment of drug resistanceOff-target effects of adhesion inhibitors
06
Interacting drugs
Bismuth
3 more in the full profile.
07
Biomarkers
BabA expressionSabA expressionLewis antigen expressionH. pylori presence in gastric biopsy
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